Browsing through sites like Etsy I see a lot of people making small sprites out of Perler Beads. Mostly it’s small things like Super Mario Bros. blocks or some such, and while cool they are not very interesting to me. But Doctor Octoroc has used these Perler Beads to make these massive sprites from MegaMan 2 (and other games):

These are constructed of over 6000 beads in multiple layers to give the project some depth. Check out the rest of his Large Bead Sprites photostream to see a fantastic Samus, MegaMan X and Gutsman Dozer.